Studies on absorption, distribution and excretion of aromatic basic ether with antispasmodic activity

Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion.

Among the group of polybrominated diphenyl ethers used as flame-retardants, the fully brominated diphenyl ether, decabromodiphenyl ether (decaBDE), is the most commonly used. Despite the large usage of decaBDE, neither the metabolic pathways nor the absorption have been addressed, and there are very few studies on its toxicology. In this work, it is shown that after a single oral dose of 14C-la...

The Absorption, Excretion, and Distribution of Penicillin.

Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols.

Recent research on the bioavailability of flavan-3-ols after ingestion of green tea by humans is reviewed. Glucuronide, sulfate, and methyl metabolites of (epi)catechin and (epi)gallocatechin glucuronide reach peak nanomolar per liter plasma concentrations 1.6-2.3 h after intake, indicating absorption in the small intestine. The concentrations then decline, and only trace amounts remain 8 h aft...

Thiouracil. Its Absorption, Distribution, and Excretion.

The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat.

The unique pharmacological properties of dimetacrine as a reserpine antagonism, central parasympathicolytic action and the occurrence of behavioral changes in cats and rats were observed by Jahn (2). The clinical properties and the value of this drug in the treatment of depressive states, and in a variety of psychic disorders have been well established (3-5). Schatz et al. (6) demonstrated the ...